World Congress on Risk 2015
19-23 July, 2015, Singapore

Online Program

Session Schedule & Abstracts

* Disclaimer: All presentations represent the views of the authors, and not the organizations that support their research. Please apply the standard disclaimer that any opinions, findings, and conclusions or recommendations in abstracts, posters, and presentations at the meeting are those of the authors and do not necessarily reflect the views of any other organization or agency. Meeting attendees and authors should be aware that this disclaimer is intended to apply to all abstracts contained in this document. Authors who wish to emphasize this disclaimer should do so in their presentation or poster. In an effort to make the abstracts as concise as possible and easy for meeting participants to read, the abstracts have been formatted such that they exclude references to papers, affiliations, and/or funding sources. Authors who wish to provide attendees with this information should do so in their presentation or poster.

Common abbreviations

Tuesday 21-07-2015

Nanotechnology Risk

Room: Discovery   13:30–15:00

Chair(s): Vicki Stone

1    Consumer perceptions of nanotechnology products. Poortvliet P.M., Wageningen University; Feindt P.H., Wageningen University (127)

Abstract: Over recent years, nanotechnologies have seen rapid development with a wide range of possible applications, including consumer products such as cosmetics, textiles and household appliances. Nanotechnology-based products are entering the market and affect daily life. However, due to lack of labeling the use of nanotechnology is often not visible to consumers, neither is the technology well understood. At the same time, successful development and marketization of innovations depends on positive perceptions and reassurance of end-users about product reliability and safety. This paper contributes to recent research on public and consumer perceptions of nanotechnology and nano-products. Within this research field, we pursue a more in-depth research methodology to understand the underlying processes of how consumers are forming perceptions and opinions about nanotechnology and products. In the current study focus group interviews were conducted with participants about their perceptions of nanotech applications, using nano-silver in cutting boards as anchorage example. In order to minimize priming effects, we took a step-by-step approach of interviewing with an increasing level of focus in the questions. In this way we explored the role of knowledge and product labeling, perceptions of benefits and risks, trust in actors, and perceived motives for buying nano-products. We held parallel focus group interviews on domestic applications of GMO technology. Comparison across technologies allows for distinguishing technology specific responses from general perceptions of novel technologies. Practical implications for risk communication of the findings are also discussed.

2    Exploring Appropriate Regulations for Nanofood in Malaysia. AWANG MN, ISLAMIC SCIENCE UNIVERSITY OF MALAYSIA (218)

Abstract: This paper contributes to the study of risk regulation by evaluating the role of law in responding to risk associated with nanofood products/foodstuffs. It primarily asks: how should we regulate the use of nanomaterials in food products? Part I of this paper elaborates on the interests over safety of nanomaterials in Malaysia. Part 2 investigates potential approaches to regulating nanofood products, drawing findings from substantive regulatory reports and informal communications with relevant experts and stakeholders. In Part 3, it analyses whether the current food legal regimes (the Food Act 1985 and Food Regulations 1985) can be applied to nanofood products/ foodstuffs and the relevance of the precautionary principle in this area. The finding demonstrates that such products are in principle covered within the existing regimes since they do not make particular reference to particle size. Although nanotechnology is not totally new, it is still pertinent to address regulatory gaps and triggers to ensure adequate human health protection is achieved through a science-based regulation. Theme: Nanomaterials and Emerging Technologies (Risk, Law and Policy)

3    A tiered framework for nano-EHS assessment. Collier ZA, US Army Engineer Research & Development Center; Kennedy AJ, US Army Engineer Research & Development Center; Steevens JA, US Army Engineer Research & Development Center (319)

Abstract: While nanotoxicology research is becoming increasingly robust and nuanced, the data generated is complex and unknowns persist. Thus, while regulatory guidance on nanotechnology risk assessment has lagged behind rapid technological developments and industrial application, regulators still must attempt to assess these risks when acquiring new technologies. The nanotechnology community as a whole lacks a formal process for obtaining adequate information for specific nanotechnologies to make risk-informed decisions and ensure rapid fielding while managing cost. There is a need for nanomaterial technologies to be distinctly defined in terms of (1) the raw parent nanomaterial that goes into the application and (2) if anything on the nanoscale is released from the application during normal use or following extensive wear and weathering. Exclusionary criteria from intensive, potentially expensive regulatory testing may be recommended if the technology involves an obviously benign nanostructured material or if nothing on the nanoscale is likely to be released. The overarching objective of this work is to outline and construct a tiered, user-friendly conceptual framework for adaptive screening and evaluation of the potential for nanomaterial-unique environmental health and safety (EHS) impacts associated with acquisition and use of nanotechnologies. The framework will provide a path for meeting regulatory considerations by (1) establishing separate handling/consideration of particles, particle technologies and nanostructured technologies; (2) considering all available data and nano risk calculations and tools prior to generating new information; and (3) standardize a nano-specific process for generating high-quality, application-relevant EHS data to in a way that is consistent, streamlined, and helps to make a risk-informed decision.

4    Toxicity of surface chemically modified Ag nanoparticles and implications for risk assessment. Pang C, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences; Zhu C, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences; Hristozov D, Department of Environmental Sciences, Informatics and Statistics, University Ca’ Foscari Venice, Italy; Chen C, CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China; Zhao B, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences (266)

Abstract: With the advance in material science, silver nanoparticles (AgNPs) are modified by different surface coating. However, the impact of these surface modifications on human health and risk is still unknown. We have evaluated the uptake, toxicity, and pharmacokinetics of AgNPs coated with citrate, polyethylene glycol, polyvinylvpyrolidone or branched polyethyleneimine (Citrate AgNPs, PEG AgNPs, PVP AgNPs or BPEI AgNPs). Our results demonstrate that the toxicity of AgNPs depends on their intracellular localization that was highly dependent on the surface charge. BPEI induced the highest cytotoxicity and DNA fragmentation in Hepa1c1c7 and also showed higher damage to the nucleus of liver cells in the exposed mice, which is associated with the highest cellular uptake and higher accumulation in liver tissues. The near neutral PEG AgNPs showed the low toxicity and the long blood circulation as well as the high bioaccumulation in spleen which suggest better biocompatibility. Moreover, the adsorption ability with BSA revealed that the PEG surface of AgNPs with an optimal biological inertia can effectively resist opsonization or non-specific binding to protein in mice. The toxicological data will be useful for making choices of AgNPs in safe design of consumer products and drug delivery applications.

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