World Congress on Risk 2015
19-23 July, 2015, Singapore

Online Program

Session Schedule & Abstracts

* Disclaimer: All presentations represent the views of the authors, and not the organizations that support their research. Please apply the standard disclaimer that any opinions, findings, and conclusions or recommendations in abstracts, posters, and presentations at the meeting are those of the authors and do not necessarily reflect the views of any other organization or agency. Meeting attendees and authors should be aware that this disclaimer is intended to apply to all abstracts contained in this document. Authors who wish to emphasize this disclaimer should do so in their presentation or poster. In an effort to make the abstracts as concise as possible and easy for meeting participants to read, the abstracts have been formatted such that they exclude references to papers, affiliations, and/or funding sources. Authors who wish to provide attendees with this information should do so in their presentation or poster.

Common abbreviations

Monday 20-07-2015

Human Health Risk Assessment: International Perspectives

Room: Breakthrough   10:15–11:45

Chair(s): Akihiro Tokai

2    Proof-of-concept weight of evidence framework to characterise the hazard of skin sensitising chemicals. Leonte D, Australian Department of Health; Rorije E, RIVM; Traas Theo, RIVM; Ezendam J, RIVM; Muller A, RIVM (327)

Abstract: A variety of types of scientific evidence, each of potentially different quality, may be available, or required, to assess the risks associated with the use of an industrial chemical in a specific context. In this abstract, the process of integrating evidence, and placing different weight on evidence of different quality, in order to make a judgment about the chemical being hazardous to human health and/or the environment is referred to as ‘weight of evidence’ (WoE). The use of WoE in chemical hazard assessment is closely aligned with developments in integrated testing strategies, which aim to maximise the use of existing data and make a hazard determination on mechanistic basis, using a variety of data sources. As our mechanistic understanding of how chemicals interact with the human body increases and new tools become available to assist with chemical hazard evaluations, there is an increased need to use WoE to both assess and manage chemical-specific risks to human health and the environment. In this talk we present a proof-of-concept regulatory WoE framework to characterise the hazard of skin sensitising chemicals. This hazard endpoint was selected due the advanced knowledge and availability of in silico and in vitro tools to replace widely-accepted and well validated in vivo tests. The proof-of-concept framework is aligned with the principles of integrated approaches to testing and assessment.

3    Development of occupational exposure assessment tool assisting voluntary risk management of industrial sectors. Haruko Yamaguchi, Osaka University; Asato Ito, Osaka University; Akihiro Tokai, Osaka University (303)

Abstract: The basic idea of the research project is to manage chemical substances especially for downstream users based on the integration of indigenous knowledge about workplace exposure. The purpose of this study is to develop an exposure assessment model that assists voluntary chemicals management by Japanese downstream industries for occupational exposure which seems to have relatively higher risk in the industrial supply chain. We have developed a probabilistic assessment tool for the occupational exposure in Japan based on the framework of Advanced REACH Tool (ART). We named this tool as SWEEs (integrated Score-based Workplace Exposure system). First, for a validation of SWEEs, we collected the observed exposure data of the organic solvent measured in some workplaces related to the automobile manufacturing industry. The result indicated that the exposure estimate was the 0.1-873 times larger than the measured data as a whole. This result suggests that continuous effort to collect relevant information on workplace exposure are strongly required. Second, to prioritize the required collected data for SWEEs, we tried to estimate the exposure probabilistic concentration and performed sensitive analysis with the case of workers exposed to toluene in gravure printing industry. As the result, the average of estimated concentration was 30.8 ppm, the 0.66 times of observed concentration (46.7ppm). In addition, modified factors such as related to local control measurement and action of workers in workplace were identified as a key parameters that contributed largely to the estimated concentration by this sensitive analysis. In parallel with this modeling study, we continue to improve model framework applicable under limited data availability condition, up to now we have examined introduction of the model for multi chemical behavior in the workplace, validation through data rich case studies. Through integrating these tasks, final goal will be the participatory evolving systems of voluntary risk management system in industrial sectors in Japan.

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