W15 - European Exposure Assessment Toolbox, Part 2Ventura 1:30 - 3:00 pm
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| Chair(s): D. Papameletiou, Mike Dourson
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W15.1 U.S. Environmental Protection Agency Perspective. T. Brennan; U.S. Environmental Protection Agency Brennan.Thomas@epamail.epa.gov
Abstract: (Note: Tom Brennan confirmed to give a presentation along the following lines. A final version of his abstact will be provided).
EPA scientists have developed an extensive set of guidance and resource documents, databases, software, and Web sites for use in performing consumer exposure assessments. For example, the documents include Guidelines for Exposure Assessment , Dermal Exposure Assessment: Principles and Applications , and the Exposure Factors Handbook . Databases include the Consolidated Human Activities Database , while software including the Exposure, Fate Assessment Screening Tool (E-FAST) are available via the Exposure Assessment Tools and Models Web site . Further, the Exposure Factors Program Web site provides up-to-date information on EPA’s human exposure factors efforts. It is widely recognized that EPA’s guidance and resource documents, databases, software, and Web sites have been of global usefulness for performing consumer exposure assessments. This has led to a recent Office of Prevention, Pesticides, and Toxic Substances, “International Toolbox” effort by EPA to note what guidance and resource documents, databases, software, and Web sites have potential global usefulness. Other potential opportunities for global collaboration (e.g., between EPA, the European Commission, and others) will be discussed.
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W15.2 Health Canada Perspective. B. Meek; Health Canada bette_meek@hc-sc.gc.ca
Abstract: (Note:Bette Meek confirmed to give a presentation along the following lines. A final version of her abstact will be provided).
This presentation will review the human exposure assessment-related efforts of Health Canada related to consumer products. This has included analytical studies to assess exposures during simulated usage of consumer products, and a detailed analysis of approaches for dermal exposure assessment. Current work includes the development of age-related consumer scenarios for various products to help define the potential for human exposure.
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W15.3 Perspective On Tiered Exposure Assessment: American Chemistry Council. R. Becker; American Chemistry Council Rick_Becker@americanchemistry.com
Abstract: Exposure assessment is integral to risk-based decision making. In the absence of agreed upon, scientifically-accepted exposure assessment approaches, decision making is often constrained solely to toxicity, yielding great uncertainty as to effectiveness, or even necessity for, risk management decisions. Exposure assessment must be promoted, as part of all risk-based chemical evaluation endeavors, in both the public & private sectors, since risk characterizations can’t be derived without integrating toxicity, dose-response & exposure. Exposure assessment’s role in product stewardship is critical. To ensure protective, science-based product stewardship, the American Chemistry Council (ACC) supports further development of tiered exposure assessment methods. The tiered approach begins with less complex, readily available information/defaults to yield a screening-level evaluation. If this screening predicts exposure is of potential concern (e.g., inadequate margin of exposure) then the next tier of exposure assessment is undertaken, using more complex, data-driven, chemical & scenario-specific methods to provide a greater degree of scientific certainty. Underlying principles to develop exposure assessments are similar, even though there is no single method or “cookbook” applicable to all substances/circumstances. In general, a flexible approach to the selection of the exposure assessment methods (software) for chemical/situation-specific concerns is recommended. At any tier, critical components are scientific quality, completeness & documentation (transparency & clarity). Development & dissemination of exposure & use information for the HPV Challenge & for the EPA’s Voluntary Children’s Chemical Evaluation Program pilot have produced challenges, lessons learned & achievements, which will be discussed in the context of the European Commission’s exposure assessment toolbox efforts.
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W15.4 International Programme on Chemical Safety, World Health Organization Perspective . C. Vickers , H. Ozkaynak, G.* Heinemeyer; International Programme on Chemical Safety, World Health Organization and U.S. Environmental Protection Agency vickersc@who.int
Abstract: (Note:IPCS/WHO confirmed to give a presentation along the following lines. A final version of their abstact will be provided).
This presentation will review the outcome of International Programme on Chemical Safety (IPCS) efforts on harmonization of approaches related to the assessment of risk from exposure to chemicals. One activity has been the IPCS Glossary of Key Exposure Assessment Terminology, intended to help facilitate communication and consistency of language in the exposure sciences. This effort included exposure route-specific case studies illustrating the definitions in the IPCS glossary. This presentation will also note new activities related to exposure assessment, e.g., on uncertainty.
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W15.5 Key Points and Conclusions from Sessions I and II.. D. Paustenbach, J. Van Engelin; ChemRisk®, USA; National Institute of Public Health and the Environment (RIVM), The Netherlands
Abstract:
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